BDBM136863 US10231967, Example 100::US8865911, 100::US9918985, Example 100

SMILES CO[C@H]1CC[C@@]2(Cc3ccc(cc3[C@@]22N=C(C)C(N)=N2)-c2cc(Cl)c(F)c(c2)C#N)CC1

InChI Key InChIKey=FMNVIPHETSINMI-LQGLAIQGSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 136863   

TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM136863(US10231967, Example 100 | US8865911, 100 | US99189...)
Affinity DataIC50:  0.720nMpH: 9.2Assay Description:TR-FRET AssayThe beta-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human beta-Secretase (AA 1-AA...More data for this Ligand-Target Pair
In DepthDetails US Patent